IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy.

Georgette TannerRhiannon BarrowShoaib AjaibMuna Al-JabriNazia AhmedSteven PollockMartina FinettiNora RippausAlexander F BrunsKhaja SyedJames A PoulterLaura MatthewsThomas HughesErica WilsonColin JohnsonFrederick S VarnAnke Brüning-RichardsonCatherine HoggAlastair DroopArief GusnantoMatthew A CareLuisa CutilloDavid R WestheadSusan C ShortMichael D JenkinsonAndrew BrodbeltAruna ChakrabartyAzzam IsmailRoel G W VerhaakLucy F Stead

Published in: Genome biology (2024)

We show that the responder subtype is cancer-cell intrinsic, recapitulated in in vitro GBM cell models, and influenced by the presence of the tumor microenvironment. Stratifying GBM tumors by responder subtype may lead to more effective treatment.

Keyphrases

gene expression
single cell
stem cells
oxidative stress
mesenchymal stem cells
bone marrow
heat shock