Bioinspired oxidation in cytochrome P450 of isomers orientin and isoorientin using Salen complexes.
Mariane B ChagasDaniel O B PontesAllan V D AlbinoEmanuel J FerreiraJovelina S F AlvesAnallicy S PaivaDaniel L PontesSilvana M Z LangansserLeandro De Santis FerreiraPublished in: Rapid communications in mass spectrometry : RCM (2020)
The formation of epoxides is common in biomimetic reactions and they may represent a safety risk in medicinal products due to their high reactivity. This study may serve as a basis for subsequent pharmacological and toxicological studies that investigate the presence of these compounds as phase I metabolites, and ensure the safe use of plant products containing orientin as a chemical marker.