Germline DNA Sequencing Reveals Novel Mutations Predictive of Overall Survival in a Cohort of Patients with Pancreatic Cancer.

Jennifer B GoldsteinLi ZhaoXuemei WangYael GhelmanMichael James OvermanMilind M JavleRachna T ShroffGauri R VaradhacharyRobert A WolffFlorencia McAllisterAndrew FutrealDavid R Fogelman

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

We have identified novel germline mutations that are prognostic for survival in patients with pancreatic cancer. We observe improved survival in patients with DDR gene mutations and worsened survival in patients with deleterious mutations in non-DDR genes.

Keyphrases

free survival
dna repair
genome wide
dna methylation
gene expression
single cell
oxidative stress
dna damage
nucleic acid