Dopamine Receptor D5 is a Modulator of Tumor Response to Dopamine Receptor D2 Antagonism.

Varun V PrabhuNeel S MadhukarCoryandar GilvaryC Leah B KlineSophie OsterWafik S El-DeiryOlivier ElementoFaye DohertyAlexander VanEngelenburgJessica DurrantRohinton S TaraporeSean DeaconNeil CharterJinkyu JungDeric M ParkMark R GilbertJessica RusertRobert Wechsler-ReyaIsabel Arrillaga-RomanyTracy T BatchelorPatrick Y WenWolfgang OsterJoshua E Allen

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)

These results implicate DRD5 as a negative regulator of DRD2 signaling and tumor sensitivity to ONC201 DRD2 antagonism.

Keyphrases

uric acid
transcription factor
metabolic syndrome