APP-derived peptides reflect neurodegeneration in frontotemporal dementia.
Ignacio Illán-GalaJordi PeguerolesVictor MontalDaniel AlcoleaEduard VilaplanaAlexandre BejaninSergi Borrego-ÉcijaFrederic SampedroAndrea SubiranaMaría-Belén Sánchez-SaudinósRicard Rojas-GarcíaHugo VandersticheleRafael BlesaJordi ClarimónAnna AntonellAlbert LladóRaquel Sánchez-ValleJuan ForteaAlberto LleóPublished in: Annals of clinical and translational neurology (2019)
APP-derived peptides in CSF may reflect FTLD-related neurodegeneration. This observation has important implications as Aβ1-42 levels are considered an indirect biomarker of cerebral amyloidosis.