HS-GC-MS analysis of volatile organic compounds after hyperoxia-induced oxidative stress: a validation study.
Thijs A LilienDominic W FennPaul BrinkmanLaura A HagensMarry R SmitNanon F L HeijnenJob B M van WoenselLieuwe D J BosReinout A Bemnull nullPublished in: Intensive care medicine experimental (2024)
Hyperoxia exposure of alveolar epithelial cells did not result in an increase in identifiable VOCs, whilst VOCs previously linked to oxidative stress were not associated with oxygen exposure in a cohort of critically ill patients. These findings suggest that the pathophysiological origin of previously proposed breath markers of oxidative stress is more complex than just oxidative stress from hyperoxia at the lung epithelial cellular level.