Highly Functionalized Ring B Labdane Synthesis as Key Intermediate in the Route to Forskolin.
Ignacio E TobalLourdes CastañedaAlejandro M RonceroRosalina F MoroDavid DiezIsidro S MarcosPublished in: Natural product communications (2019)
Sclareol has been employed as starting material for the synthesis of several advanced intermediates towards the synthesis of highly ring B oxygenated labdanes. Dinorlabdanes 6,7,8,9-tetraoxygenated with 6,7-dioxygenated functionalities with a-cis or O-cis dispositions, have been prepared and can be used for forskolin or analogues synthesis.