Extracellular vesicles derived from tumour cells as a trigger of energy crisis in the skeletal muscle.

Fabrizio PinMarc BeltràLorena Garcia-CastilloBarbara PardiniGiovanni BiroloGiuseppe MatulloFabio PennaDenis GuttridgePaola Costelli

Published in: Journal of cachexia, sarcopenia and muscle (2021)

These results show that in C2C12 cultures, TMVs are able to affect both differentiation and the mitochondrial system. Such effects could be related to TMV-contained miRs.

Keyphrases

skeletal muscle
induced apoptosis
cell cycle arrest
oxidative stress
public health
insulin resistance
endoplasmic reticulum stress
type diabetes
cell death
metabolic syndrome
adipose tissue
drug induced