Association of human beta-defensin 1 gene polymorphisms with nonsegmental vitiligo.
Luis Antonio Ochoa-RamirezD S Becerra-LoaizaS P Díaz-CamachoV F Muñoz-EstradaE R Ríos-BurgueñoE Prado-Montes de OcaH Rangel-VillalobosJ S Velarde-FélixPublished in: Clinical and experimental dermatology (2018)
The -44 G allele, CG genotype and GGG haplotype increased the risk for vitiligo (P < 0.02 in all cases), whereas the -20 AA genotype seems to be protective (P = 0.04). Serum HBD-1 levels were lower in patients with vitiligo than in HCs (P < 0.01), as well as in patients with active vitiligo compared with those with stable vitiligo and with HCs (P < 0.05 in both cases), CONCLUSION: Our results suggest that HBD-1 and its gene polymorphisms may modulate vitiligo susceptibility and/or disease activity. This is the first report, to our knowledge, of the association of serum HBD-1 levels and DEFB1 gene polymorphisms with vitiligo.