Lactobacillus lactis and Pediococcus pentosaceus-driven reprogramming of gut microbiome and metabolome ameliorates the progression of non-alcoholic fatty liver disease.
Jeong Seok YuGi Soo YounJieun ChoiChang-Ho KimByung Yong KimSeung-Jo YangJe Hee LeeTae-Sik ParkByoung Kook KimYeon Bee KimSeong Woon RohByeong Hyun MinHee Jin ParkSang Jun YoonNa Young LeeYe Rin ChoiHyeong Seob KimHaripriya GuptaHotaik SungSang Hak HanKi-Tae SukDo Yup LeePublished in: Clinical and translational medicine (2022)
NAFLD progression was robustly associated with metabolic dys-regulations in the SCFAs, bile acid and indole compounds, and NAFLD can be accurately diagnosed using the metabolites. L. lactis and P. pentosaceus ameliorate NAFLD progression by modulating gut metagenomic and metabolic environment, particularly tryptophan pathway, of the gut-liver axis.