Antihyperalgesia effect of AMP-activated protein kinase (AMPK) activators in a mouse model of postoperative pain.

Vaskar DasJeffrey S KroinMario MoricRobert J McCarthyAsokumar Buvanendran

Published in: Regional anesthesia and pain medicine (2019)

Early treatment with the mechanism-specific AMPK activator O304 or the prototype AMPK activator metformin reduces mechanical hypersensitivity in a postoperative pain model in mice. These drugs also normalize the AMPK pathway in the DRG.

Keyphrases

protein kinase
postoperative pain
skeletal muscle
mouse model
nuclear factor
drug induced
insulin resistance
high fat diet induced
immune response
toll like receptor
replacement therapy