Leukocyte surface biomarkers implicate deficits of innate immunity in sporadic Alzheimer's disease.

Xin HuangYihan LiChristopher FowlerJames D DoeckeYen Ying LimCandace DrysdaleVicky ZhangKeunha ParkBrett TrounsonKelly PertileRebecca RumbleJohn W PickeringRobert A RissmanFloyd SarsozaSara Abdel-LatifYong LinVincent DoréVictor VillemagneChristopher C RoweJurgen FrippRalph MartinsJames S WileyPaul MaruffJacobo E MintzerColin L MastersBen J Gu

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2022)

Our finding of changes on peripheral leukocyte surface antigens in AD implicates the deficit in innate immunity. Leukocyte-based biomarkers prove to be both sensitive and practical for AD screening and diagnosis.

Keyphrases

peripheral blood
traumatic brain injury
late onset
cognitive decline
dendritic cells
amyotrophic lateral sclerosis
early onset