Predictors of decreased bone mineral density in childhood systemic lupus erythematosus: possible role of osteoprotegerin gene polymorphisms.
Riham EidMaha AbdelsalamAya A FathyDena M Abd-El GhaffarEman B ElmarghanyAya A El-HanafyNora MostafaAya Ahmed El-HanafyNermeen A NiazyAyman HammadHadil M AboleneinPublished in: Journal of pediatric endocrinology & metabolism : JPEM (2021)
This is the first study to demonstrate OPG gene influence on BMD in children with SLE. The studied SNPs are not risk for developing SLE but, rs2073617 T allele is a possible predictor for reduced BMD in SLE. Other predictors include long disease duration and high activity supporting that osteoporosis in SLE is multifactorial.