Genome-wide association study of asthma exacerbations despite inhaled corticosteroid use.
Natalia Hernandez-PachecoSusanne J VijverbergEsther Herrera-LuisJiang LiYang Yie SioRaquel GranellAlmudena CorralesCyrielle MaroteauRyan LethemJavier Perez-GarciaNiloufar FarzanKatja RepnikMario GorenjakPatricia SoaresLeila KarimiMaximilian SchieckLina I Pérez-MéndezVojko BerceRoger TavendaleCeleste EngOlaia Sardón PradoInger KullSomnath MukhopadhyayMunir PirmohamedKatia M C VerhammeEsteban G BurchardMichael KabeschDaniel B HawcuttErik MelénUroš PotočnikFook Tim ChewKelan G TantisiraStephen W TurnerColin N PalmerCarlos FloresMaria Pino-YanesAnke H Maitland-van der Zeenull nullPublished in: The European respiratory journal (2021)
The intergenic region of CACNA2D3 and WNT5A was revealed as a novel locus for asthma exacerbations despite ICS treatment in European populations. Genes associated were related to trichostatin A, suggesting that this drug could regulate the molecular mechanisms involved in treatment response.