Ductal Carcinoma In Situ (DCIS) Diagnosed by MRI-Guided Biopsy among <i>BRCA1/BRCA2</i> Mutation Carriers.

MRI-detected noncalcified DCIS is more frequent in <i>BRCA1</i> PSV carriers compared with <i>BRCA2</i> carriers, unlike the <i>BRCA2</i> predominance in mammography-detected calcified DCIS. <i>BRCA1</i>-related DCIS is diagnosed earlier, more likely to be estrogen receptor-negative and of higher grade compared with <i>BRCA2</i>-related DCIS. Future prospective studies should validate these results and assess the actual impact they might have on clinical management of <i>BRCA</i> PSV carriers.