Mesenchymal stromal cells secretome restores bioenergetic and redox homeostasis in human proximal tubule cells after ischemic injury.

João Faria Sandra Calcat-I-Cervera Renata SkovronovaBonnie C BroeksmaAlinda J BerendsEsther A Zaal Benedetta Bussolati Timothy O'Brien Silvia M Mihăilă Rosalinde Masereeuw

Published in: Stem cell research & therapy (2023)

Our in vitro model effectively replicated the in vivo-like morphological and molecular changes observed during ischemic injury. Additionally, treatment with MSC secretome ameliorated proximal tubule damage, highlighting its potential as a viable therapeutic option for targeting AKI.

Keyphrases

induced apoptosis
endothelial cells
ischemia reperfusion injury
acute kidney injury
oxidative stress
cell cycle arrest
bone marrow
cerebral ischemia
cancer therapy
induced pluripotent stem cells
endoplasmic reticulum stress
signaling pathway
cell death
drug delivery
brain injury