Tonantzitlolone is a nanomolar potency activator of transient receptor potential canonical 1/4/5 channels.

Hussein N RubaiyMelanie J LudlowKarsten SiemsKatherine NormanRichard FosterDietmar WolfJohn A BeutlerDavid J Beech

Published in: British journal of pharmacology (2018)

TZL is a novel potent agonist for TRPC1/4/5 channels, which should be useful for testing the functionality of this type of ion channel and understanding how TRPC1/4/5 agonists achieve selective cytotoxicity against certain types of cancer cell.

Keyphrases

vascular smooth muscle cells
cerebral ischemia
human health
angiotensin ii
binding protein
immune response