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Inactivation of Notch4 Attenuated Pancreatic Tumorigenesis in Mice.

Kiyoshi SaekiWanglong QiuRichard A FriedmanSamuel S PanJordan LuShu IchimiyaIok In Christine ChioCarrie J ShawberJan K KitajewskiJianhua HuGloria H Su
Published in: Cancer research communications (2022)
significantly improved the survival of an aggressive mouse model for PDAC and provided preclinical evidence that Notch4 and Pcsk5 are novel targets for PDAC therapies.
Keyphrases
  • mouse model
  • cell proliferation
  • high fat diet induced
  • cell therapy
  • mesenchymal stem cells
  • low density lipoprotein
  • free survival
  • skeletal muscle
  • adipose tissue