Resveratrol is a polyphenolic plant extract with many biological activities such as anti-inflammation and anti-oxidative stress. Vascular endothelial cell (VEC) is the main sites for maintaining normal vascular permeability and participating in vasomotor regulation and substance exchange. VEC injury plays a key role in various diseases or pathological processes such as cardiovascular disease, chronic inflammation and sepsis. Studies have shown that resveratrol protects VEC and reduces endothelial damage by regulating nitric oxide (NO) and its related enzymes, reducing oxidative stress and inhibiting apoptosis, thereby exerting beneficial effects.
Keyphrases
- oxidative stress
- endothelial cells
- cardiovascular disease
- nitric oxide
- diabetic rats
- ischemia reperfusion injury
- dna damage
- high glucose
- induced apoptosis
- vascular endothelial growth factor
- acute kidney injury
- type diabetes
- heat shock
- nitric oxide synthase
- cell proliferation
- endoplasmic reticulum stress
- coronary artery disease
- drug induced
- cardiovascular risk factors
- pi k akt