A novel interaction between CX3CR1 and CCR2 signalling in monocytes constitutes an underlying mechanism for persistent vincristine-induced pain.

Karli MontagueRaffaele SimeoliJoao ValenteMarzia Malcangio

Published in: Journal of neuroinflammation (2018)

Our data suggests that CCL2/CCR2 signalling plays a crucial role in VCR-induced allodynia in CX3CR1-deficient mice, which arises as a result of an interaction between CX3CR1 and CCR2 in monocytes.

Keyphrases

dendritic cells
high glucose
regulatory t cells
diabetic rats
neuropathic pain
chronic pain
drug induced
peripheral blood
immune response
spinal cord injury
big data
spinal cord
liver fibrosis
postoperative pain