Whole-Exome Sequencing Reveals the Genomic Features of the Micropapillary Component in Ground-Glass Opacities.

Fanchen MengYi ZhangSiwei WangTongyan LiuMengting SunHongyu ZhuGuozhang DongZhijun XiaJing YouXiangru KongJintao WuPeng ChenFangwei YuanXinyu YuYoutao XuLin XuRong Yin

Published in: Cancers (2022)

Our results revealed specific mutational characteristics of the micropapillary component of invasive LUAD in an Asian population. These characteristics were associated with the formation of high-grade invasive patterns. These preliminary findings demonstrated the potential of targeting the micropapillary component in patients with early-stage LUAD.

Keyphrases

high grade
early stage
low grade
cancer therapy
single cell
copy number
radiation therapy
sentinel lymph node
locally advanced