DELAYED TXA AFTER TBI IMPEDES LEARNING, MEMORY; EARLY TXA IS FAVORABLE BUT NOT IN SHAM ANIMALS.

Matthew C CulkinMichael CoonsPriyanka BeleAdvait ThaplooAnastasia P GeorgesErin AndersonKevin D BrowneChristina JacovidesPatricia SantosLewis J KaplanDavid F MeaneyDouglas H SmithJose L Pascual

Published in: The journal of trauma and acute care surgery (2023)

Early TXA appears beneficial for cognitive and behavioral outcomes following TBI, though administration 24 h post-injury consistently impairs cognitive recovery. TXA in sham animals may lead to adverse effects on cognition.

Keyphrases

traumatic brain injury
severe traumatic brain injury
double blind
working memory
emergency department
mild cognitive impairment
clinical trial
white matter