Does failed mapping predict sentinel lymph node metastasis in cN0 breast cancer?
Francesca MagnoniGiovanni CorsoLaura GilardiEleonora PaganGiulia MassariAntonia GirardiFederico GhidinelliVincenzo BagnardiViviana GalimbertiChiara Maria GranaPaolo VeronesiPublished in: Future oncology (London, England) (2021)
Aims: The clinical significance of nonvisualized sentinel lymph nodes (non-vSLNs) is unknown. The authors sought to determine the incidence of non-vSLNs on lymphoscintigraphy, the identification rate during surgery, factors associated with non-vSLNs and related axillary management. Patients & methods: A total of 30,508 consecutive SLN procedures performed at a single institution from 2000 to 2017 were retrospectively studied. Associations between clinicopathological factors and the identification of SLNs during surgery were assessed. Results: Non-vSLN occurred in 525 of the procedures (1.7%). In 73.3%, at least one SLN was identified intraoperatively. Nodal involvement was only significantly associated with SLN nonidentification (p < 0.001). Conclusion: Patients with non-vSLN had an increased risk for SLN metastasis. The detection rate during surgery was consistent, reducing the amount of unnecessary axillary dissection.
Keyphrases
- sentinel lymph node
- lymph node
- neoadjuvant chemotherapy
- minimally invasive
- early stage
- coronary artery bypass
- end stage renal disease
- surgical site infection
- ejection fraction
- chronic kidney disease
- peritoneal dialysis
- squamous cell carcinoma
- locally advanced
- risk factors
- coronary artery disease
- radiation therapy
- acute coronary syndrome
- mass spectrometry
- real time pcr
- atrial fibrillation
- drug induced
- loop mediated isothermal amplification