A near-infrared GPX4 fluorescent probe for non-small cell lung cancer imaging.

Qiao HuWanjie ZhuJianjun DuSaran LongWen Sun Jiangli Fan Xiaojun Peng

Published in: Chemical communications (Cambridge, England) (2023)

Glutathione peroxidase 4 (GPX4) is overexpressed in non-small cell lung cancer (H1299) cells. In this work, a near-infrared fluorescent probe ENBO-ML210 was developed. In vitro and in vivo imaging results showed that ENBO-ML210 could target and visualize GPX4 in H1299 cells, exhibiting potential for the diagnosis of non-small lung cancer.

Keyphrases

fluorescent probe
living cells
induced apoptosis
cell cycle arrest
high resolution
endoplasmic reticulum stress
signaling pathway
oxidative stress
hydrogen peroxide
cell proliferation
nitric oxide
risk assessment
single molecule
pi k akt