Detection of brain lesions after catheter ablation depends on imaging criteria - Insights from AXAFA-AFNET 5 trial.
Karl Georg HaeuslerFelizitas A EichnerPeter Ulrich HeuschmannJochen B FiebachTobias EngelhornDavid CallansTom J R De PotterPhilippe DebruyneDaniel ScherrGerhard HindricksHussein R Al-KhalidiLluis MontWon Yong KimJonathan P PicciniUlrich SchottenSakis ThemistoclakisLuigi Di BiasePaulus F KirchhofPublished in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2023)
The pre-specified AXAFA-AFNET 5 sub-analysis revealed significantly increased rates of MRI-detected acute brain lesions using hrDWI instead of standard DWI in AF patients undergoing ablation. In comparison to DWI slice thickness, MRI field strength had a no significant impact in the trial. Comparing the varying rate of ablation-related MRI-detected brain lesions across previous studies have to consider these technical parameters. Future studies should use hrDWI, as feasibility was demonstrated in the multicenter AXAFA-AFNET 5 trial.
Keyphrases
- diffusion weighted imaging
- catheter ablation
- contrast enhanced
- atrial fibrillation
- phase iii
- magnetic resonance imaging
- resting state
- study protocol
- diffusion weighted
- white matter
- patients undergoing
- phase ii
- clinical trial
- left atrial
- functional connectivity
- cerebral ischemia
- high resolution
- left atrial appendage
- liver failure
- computed tomography
- optical coherence tomography
- magnetic resonance
- multiple sclerosis
- case control
- radiofrequency ablation
- mass spectrometry
- double blind
- brain injury
- respiratory failure
- intensive care unit
- extracorporeal membrane oxygenation
- label free
- left ventricular
- image quality
- quantum dots