Specific depletion of resident microglia in the early stage of stroke reduces cerebral ischemic damage.
Ting LiJin ZhaoWenguang XieWanru YuanJing GuoShengru PangWen-Biao GanDiego Gómez-NicolaSheng-Xiang ZhangPublished in: Journal of neuroinflammation (2021)
These results suggest that activated microglia is an important modulator of the brain's inflammatory response in stroke, contributing to neurological deficit and infarct expansion. Modulation of the inflammatory response through the elimination of microglia at a precise time point may be a promising therapeutic approach for the treatment of cerebral ischemia.
Keyphrases
- cerebral ischemia
- inflammatory response
- subarachnoid hemorrhage
- early stage
- blood brain barrier
- brain injury
- lipopolysaccharide induced
- lps induced
- toll like receptor
- acute myocardial infarction
- atrial fibrillation
- patient safety
- oxidative stress
- heart failure
- radiation therapy
- squamous cell carcinoma
- spinal cord injury
- replacement therapy
- neoadjuvant chemotherapy
- locally advanced
- functional connectivity