Sympathetic Hyperactivity, Increased Tyrosine Hydroxylase and Exaggerated Corpus Cavernosum Relaxations Associated with Oxidative Stress Plays a Major Role in the Penis Dysfunction in Townes Sickle Cell Mouse.
Fábio Henrique SilvaMário A ClaudinoFabiano B CalmasiniEduardo C AlexandreCarla Franco-PenteadoArthur L BurnettEdson AntunesFernando F CostaPublished in: PloS one (2016)
Our study shows that decreased nitric oxide bioavailability in erectile tissue due to increased oxidative stress leads to both sympathetic hyperactivity and dysregulation of nitric oxide signaling in corpus cavernosum from Townes sickle mice.