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CDK12 orchestrates super-enhancer-associated CCDC137 transcription to direct hepatic metastasis in colorectal cancer.

Wei DaiJunhong WuXiaopeng PengWen HouHao HuangQilai ChengZhiping LiuWalter LuytenLiliane SchoofsJingfeng ZhouSheng-Lan Liu
Published in: Clinical and translational medicine (2022)
Our data highlight the potential of CDK12 and SE-associated oncogenic transcripts as therapeutic targets for patients with liver metastatic CRC.
Keyphrases
  • transcription factor
  • cell cycle
  • squamous cell carcinoma
  • small cell lung cancer
  • electronic health record
  • big data
  • binding protein
  • cell proliferation
  • machine learning