Causes and attributable fraction of death from ARDS in inflammatory phenotypes of sepsis.
Bruno EvrardPratik SinhaKevin DelucchiCarolyn M HendricksonKirsten N KangelarisKathleen D LiuAndrew WillmoreNelson WuLucile NeytonEmma SchmiegeAntonio GomezV Eric KerchbergerAnn ZaluckyMichael A MatthayLorraine B WareCarolyn S CalfeePublished in: Critical care (London, England) (2024)
is modest in both phenotypes whereas primary cause of death among patients with sepsis differed substantially by phenotype. This study identifies challenges in powering future clinical trials to detect changes in mortality outcomes among patients with sepsis and ARDS.
Keyphrases
- septic shock
- acute kidney injury
- intensive care unit
- clinical trial
- acute respiratory distress syndrome
- mechanical ventilation
- extracorporeal membrane oxygenation
- genome wide
- oxidative stress
- cardiovascular events
- risk factors
- type diabetes
- metabolic syndrome
- cardiovascular disease
- dna methylation
- gene expression
- open label
- phase ii
- insulin resistance
- study protocol