Beyond type 2 asthma biomarkers: risk stratification for NSAID-exacerbated respiratory disease.

Jacqueline Pérez-Pazos Asunción García-Sánchez Miguel Estravís Emma Moreno-Jimenez Natalia Morgado Manuel Gómez-GarcíaJacinto Ramos-GonzálezMaría Gil-MelcónCristina Martín-García Francisco Javier Muñoz-Bellido Catalina Sanz María Isidoro-García Ignacio Dávila González

Published in: ERJ open research (2024)

We validated the transcriptomic data of five differentially expressed genes in T2 asthma. Different patterns of association were identified in patient stratification, suggesting that different molecular mechanisms underlie the spectrum of T2 asthma. Potential biomarkers were also found and used to design an algorithm with practical diagnostic utility for T2 asthma, including risk stratification for N-ERD.

Keyphrases

chronic obstructive pulmonary disease
lung function
allergic rhinitis
machine learning
case report
big data
transcription factor