SIRT3 Activator Honokiol Inhibits Th17 Cell Differentiation and Alleviates Colitis.
Xiaotian ChenMingming ZhangFan ZhouZhengrong GuYuan LiTing YuChunyan PengLixing ZhouXiangrui LiDandan ZhuXiaoqi ZhangChenggong YuPublished in: Inflammatory bowel diseases (2023)
Our study demonstrated that HKL could partially protect against colitis by regulating Th17 differentiation through activating SIRT3, leading to inhibition of the STAT3/RORγt signaling pathway. These results provide new insights into the protective effects of HKL against colitis and may facilitate the research of new drugs for inflammatory bowel disease.