Gonadotropins as novel active partners in vascular diseases: Insight from angiogenic properties and thrombotic potential of endothelial colony-forming cells.
Grégoire DétrichéNicolas GendronAurélien PhilippeMaxime GruestPaul BilloirElisa RossiCoralie L GuerinAnna LokajczykSéverine BrabantDominique PriéTristan MiraultDavid M SmadjaPublished in: Journal of thrombosis and haemostasis : JTH (2021)
Gonadotropins increase ECFC-related angiogenesis and may be involved in thrombin generation in cardiovascular disease. Gonadotropins may act as biomarkers; moreover, we hypothesize that gonadotropin-blocking strategies may be a novel interesting therapeutic approach in atherosclerotic cardiovascular disease.
Keyphrases
- cardiovascular disease
- endothelial cells
- induced apoptosis
- cell cycle arrest
- type diabetes
- cardiovascular risk factors
- vascular endothelial growth factor
- cardiovascular events
- oxidative stress
- human health
- cell death
- signaling pathway
- endoplasmic reticulum stress
- hepatitis c virus
- pi k akt
- men who have sex with men
- human immunodeficiency virus