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HMGB1 regulates Th17 cell differentiation and function in patients with psoriasis.

Xiaofeng ZhuYue DouYawen LinGaoping ChuJing WangLei Ma
Published in: Immunity, inflammation and disease (2024)
HMGB1 can contribute to the pathogenesis of psoriasis by regulating Th17 cell differentiation through HMGB1-TLR4-IL-23-RORγt pathway, then promotes IL-17A production and aggravates inflammation process. Targeting HMGB1 may be a possible potential candidate for the immunotherapy of psoriasis.
Keyphrases
  • oxidative stress
  • atopic dermatitis
  • inflammatory response
  • immune response
  • toll like receptor
  • drug delivery
  • climate change
  • human health