Impact of Age on Pharmacogenomics and Treatment Outcomes of B-Cell Acute Lymphoblastic Leukemia.

Satoshi YoshimuraZhenhua LiYoshihiro GochoWenjian Yang Kristine R CrewsShawn H R LeeKathryn G Roberts Charles G Mullighan Mary V Relling Jiyang Yu Allen Eng-Juh Yeoh Mignon L LohCaner SayginMark R Litzow Sima Jeha Seth E Karol Hiroto Inaba Ching-Hong Pui Marina Y Konopleva Nitin Jain Wendy StockElisabeth PaiettaElias J Jabbour Steven Mitchell KornblauWilliam E EvansJun J Yang

Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2024)

Our results provide pharmacogenomic insights into age-related disparities in ALL cure rates and identify leukemia prognostic features for treatment individualization across age groups.

Keyphrases

acute lymphoblastic leukemia
clinical decision support
bone marrow
acute myeloid leukemia
allogeneic hematopoietic stem cell transplantation
adverse drug
health insurance
drug induced