Impaired tumor necrosis factor-α secretion by CD4 T cells during respiratory syncytial virus bronchiolitis associated with recurrent wheeze.
Maleewan KitcharoensakkulLeonard B BacharierHuiqing Yin-DeclueJonathan S BoomerGeneline SajolMarilyn K LeungBrad WilsonKenneth B SchechtmanJohn P AtkinsonJonathan M GreenMario CastroPublished in: Immunity, inflammation and disease (2020)
We demonstrated lower TNF-α production by in vitro stimulated CD4+ T cells during severe RSV bronchiolitis in children that subsequently developed recurrent wheezing, compared with children with no subsequent wheeze. These findings support the role of CD4+ T cell immunity in the development of subsequent wheezing in these children.