Hypoxia Attenuates Pressure Overload-Induced Heart Failure.

Natali FroeseMalgorzata Szaroszyk Paolo Galuppo Joseph R Visker Christopher Werlein Mortimer Korf-Klingebiel Dominik Berliner Marc R Reboll Rana Hamouche Simona Gegel Yong Wang Winfried HofmannMing TangRobert Geffers Adam R Wende Mark P Kühnel Danny D Jonigk Georg Hansmann Kai C Wollert E Dale Abel Stavros G Drakos Johann Bauersachs Christian Riehle

Published in: Journal of the American Heart Association (2024)

Hypoxia attenuates LVPO-induced heart failure. Cardioprotective pathways identified in the HxTAC model might also contribute to cardiac recovery following left ventricular assist device support. These data highlight the potential of our novel HxTAC model to identify hypoxia-mediated cardioprotective mechanisms and therapeutic targets that attenuate LVPO-induced heart failure and mediate cardiac recovery following mechanical circulatory support.

Keyphrases

heart failure
high glucose
left ventricular
endothelial cells
diabetic rats
left ventricular assist device
drug induced
atrial fibrillation
oxidative stress
cardiac resynchronization therapy
acute heart failure
machine learning
risk assessment
climate change
artificial intelligence