Lung metastases at the initial diagnosis of high-grade osteosarcoma: prevalence, risk factors and prognostic factors. A large population-based cohort study.
Chao ZhangXu GuoYao XuXiuxin HanJun CaiXin WangGuowen WangPublished in: Sao Paulo medical journal = Revista paulista de medicina (2020)
The factors revealed here may guide lung metastasis screening and prophylactic treatment for osteosarcoma patients. A primary tumor in an axial location, greater primary tumor size, higher lymph node stage and presence of bone or brain metastases were significantly correlated with lung metastases. The elderly group (≥ 60 years) showed significant correlation with poor overall survival. For improved survival among high-grade osteosarcoma patients with lung metastases, aggressive surgery on the primary tumor site should be encouraged.
Keyphrases
- prognostic factors
- high grade
- risk factors
- lymph node
- brain metastases
- low grade
- end stage renal disease
- small cell lung cancer
- chronic kidney disease
- minimally invasive
- bone mineral density
- squamous cell carcinoma
- coronary artery bypass
- neoadjuvant chemotherapy
- postmenopausal women
- coronary artery disease
- body composition
- rectal cancer
- combination therapy
- percutaneous coronary intervention