Microvascular Network Remodeling in the Ischemic Mouse Brain Defined by Light Sheet Microscopy.

Nina Hagemann Yachao Qi Ayan Mohamud Yusuf AnRan Li Anthony Squire Tobias Tertel Bernd Giebel Peter Ludewig Philippa Spangenberg Jianxu Chen Axel Mosig Matthias Gunzer Janine Gronewold

Published in: Arteriosclerosis, thrombosis, and vascular biology (2024)

Utilizing light sheet microscopy together with automated image analysis, we characterized microvascular remodeling in the ischemic lesion core in unprecedented detail. This technology will significantly advance our understanding of microvascular restorative processes and pave the way for novel treatment developments in the stroke field.

Keyphrases

high throughput
single molecule
high resolution
high speed
cerebral ischemia
optical coherence tomography
machine learning
ischemia reperfusion injury
atrial fibrillation
deep learning
oxidative stress
single cell
replacement therapy
subarachnoid hemorrhage
blood brain barrier