Alkaloids with Immunosuppressive Activity from the Bark of Pausinystalia yohimbe.
Ye LiuHeng-Yi YuHong-Zhe XuJun-Jun LiuXiang-Gao MengMing ZhouHan-Li RuanPublished in: Journal of natural products (2018)
Ten new alkaloids (1-10), including two pairs of enantiomeric mixtures (5a,b and 6a,b), and 15 known analogues (11-25) were obtained from the bark of Pausinystalia yohimbe. The structures of 1-25 were established by spectroscopic methods, and the absolute configurations of compounds 1-10 were resolved by X-ray diffraction and ECD data analyses. The in vitro immunosuppressive activities of selected isolates were tested. Compounds 11 and 16 exhibited moderate inhibition with IC50 values of 16.8 and 27.6 μM against ConA-induced T lymphocyte proliferation and 13.5 and 40.5 μM against LPS-induced B lymphocyte proliferation, respectively.
Keyphrases
- lps induced
- inflammatory response
- molecular docking
- signaling pathway
- high resolution
- peripheral blood
- high glucose
- diabetic rats
- ionic liquid
- electron microscopy
- big data
- drug induced
- oxidative stress
- computed tomography
- machine learning
- dual energy
- genetic diversity
- artificial intelligence
- magnetic resonance imaging
- data analysis
- structure activity relationship