Mesenchymal stem cell transplantation attenuates growth of chemotherapy treated oral squamous cell carcinoma in an animal model.
Marika ZurmukhtashviliAvtandil MachavarianiGiorgi DugashviliTeimuraz GrdzelidzeKetevan GogilashviliGiorgi MenabdeIvane AbiatariLuc A M MarksPublished in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2020)
The study demonstrates that intra-tumorally injected MSCs, combined with Cisplatin, leads to a minimal hypoxia status and increased apoptotic activity in tumor tissues, compared with the control group. This finding can be explained with better distribution of Cisplatin due to increased angiogenesis.