Whole genome sequencing of Trypanosoma cruzi field isolates reveals extensive genomic variability and complex aneuploidy patterns within TcII DTU.
João Luís Reis-CunhaRodrigo P BaptistaGabriela F Rodrigues-LuizAnderson Coqueiro-Dos-SantosHugo O ValdiviaLaila Viana de AlmeidaMariana Santos CardosoDaniella Alchaar D'ÁvilaFernando Hugo Cunha DiasRicardo Toshio FujiwaraLúcia M C GalvãoEgler ChiariGustavo Coutinho CerqueiraDaniella Castanheira BartholomeuPublished in: BMC genomics (2018)
Analysis of genomic variability and aneuploidies suggests that there is significant genomic variability within Minas Gerais TcII strains, which could be exploited by the parasite to allow rapid selection of favorable phenotypes. Also, the aneuploidy patterns vary among T. cruzi strains and does not correlate with the nuclear phylogeny, suggesting that chromosomal duplication/loss are recent and frequent events in the parasite evolution.