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Medically induced hypertension, hypervolaemia and haemodilution for the treatment and prophylaxis of vasospasm following aneurysmal subarachnoid haemorrhage: systematic review.

James J M LoanAnthony N WigginsPaul M Brennan
Published in: British journal of neurosurgery (2018)
There is currently insufficient evidence to determine the efficacy or non-efficacy of intravenous volume expansion, medically induced hypertension or blood transfusion for the treatment or prophylaxis of vasospasm following SAH. All of these approaches have been associated with adverse events, of unclear incidence. The current evidence base therefore cannot be used to reliably inform clinical practice. This is a priority for further research.
Keyphrases
  • systematic review
  • blood pressure
  • subarachnoid hemorrhage
  • clinical practice
  • high glucose
  • diabetic rats
  • meta analyses
  • drug induced
  • low dose
  • endothelial cells
  • brain injury
  • combination therapy
  • cerebral ischemia