Therapeutic anti-amyloid β antibodies cause neuronal disturbances.

Utpal Kumar AdhikariRizwan KhanMeena MikhaelRachelle BalezMonique Antoinette DavidDavid MahnsJohn HardyMourad Tayebi

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2022)

Allergenic-related proteins are often linked with Alzheimer's disease (AD). We investigated the effects of amyloid beta (Aβ) immunotherapy on stem cell derived neurons and primary neuronal cells co-cultured with microglia. Anti-Aβ antibody treatment of neurons or neurons co-cultured with microglia led to activation of a substantial number of allergenic-related genes. These allergenic-related genes are associated with endothelial dysfunction possibly responsible for ARIA.

Keyphrases

spinal cord
neuropathic pain
inflammatory response
endothelial cells
induced apoptosis
cell cycle arrest
spinal cord injury
cognitive decline
oxidative stress
endoplasmic reticulum stress
signaling pathway
high resolution
smoking cessation
single molecule
light emitting