Corneal endothelial cell morphology in children with autosomal recessive Alport syndrome: a longitudinal study.

Published in: Ophthalmic genetics (2024)

Measurement of ECD and percentage of hexagonality can also be used as an indicator of the health of the corneal endothelium. In this study, the mean ECD and HEX were significantly lower in ARAS group than in age-matched pediatric controls. Polymegathism, which reflects cellular stress, was statistically significantly higher in ARAS group. The mean ECD and CCT decreased significantly at 1-year follow-up. This study may demostrated that endothelial damages and stress in ARAS patients appear in childhood and show a rapid increase with age.

Keyphrases

endothelial cells
end stage renal disease
optical coherence tomography
newly diagnosed
risk assessment
prognostic factors
climate change
health information
heat stress
patient reported outcomes
social media
early life
childhood cancer
muscular dystrophy