ADAM12 promotes gemcitabine resistance by activating EGFR signaling pathway and induces EMT in bladder cancer.

Runchang WangDongyang GaoChaohu ChenGuangrui FanHui ChengYan TaoJianzhong LuJunqiang TianYuhan WangZhiping Wang

Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2022)

Our findings suggested that ADAM12 was a key gene for GEM resistance and positively correlated with malignancy of BC. It might serve as a novel and valuable therapeutic target for BC.

Keyphrases

signaling pathway
epithelial mesenchymal transition
small cell lung cancer
pi k akt
epidermal growth factor receptor
genome wide
tyrosine kinase
copy number
induced apoptosis
gene expression
locally advanced
cell proliferation