UBE3A and transsynaptic complex NRXN1-CBLN1-GluD1 in a hypothalamic VMHvl-arcuate feedback circuit regulates aggression.

Yi NongDavid C StoppelMark A JohnsonMorgane BoillotJelena TodorovicJason ShenXinyu ZhouMonica J S NadlerCarrie RodriguezYuda HuoIkue NagakuraEkkehard M KasperMatthew P Anderson

Published in: bioRxiv : the preprint server for biology (2023)

A feedback circuit in the hypothalamus that inhibits aggression is impaired by converging autism genetic defects.

Keyphrases

autism spectrum disorder
intellectual disability
genome wide
copy number