Characterization of Diclofenac-induced Renal Damage in Normotensive and Hypertensive Rats: A Comparative Analysis.
Thaise BoeingAlana Bittencourt F LimaMaria Eduarda BusanaLuísa Nathália Bolda MarianoLuisa Mota da SilvaRita de Cássia Vilhena da SilvaPriscila DE SouzaPublished in: Drug research (2024)
The data presented herein demonstrated that diclofenac induces renal damage and impaired renal function in both NTR and SHR, but those effects are exacerbated in SHR, as seen by the histological changes and electrolytes balance disturbance, therefore, reinforcing that diclofenac may increase the risks of cardiovascular events in hypertensive patients.