Experimental dopaminergic neuron lesion at the area of the biological clock pacemaker, suprachiasmatic nuclei (SCN) induces metabolic syndrome in rats.
Shuqin LuoMichael EzrokhiNicholas CominosTsung-Huang TsaiCarl R StoelzelYelena TrubitsynaAnthony H CincottaPublished in: Diabetology & metabolic syndrome (2021)
These findings indicate that reduced dopaminergic neuronal activity in neurons at the area of and communicating with the SCN contributes significantly to increased sympathetic tone and the development of metabolic syndrome, without effect on feeding.