Pharmacological Inhibition of P-Rex1/Rac1 Axis Blocked Angiotensin II-Induced Cardiac Fibrosis.

Jianyuan PanMing LiuHuimin SuHao HuHongwu ChenLikun Ma

Published in: Cardiovascular drugs and therapy (2023)

Our findings demonstrated for the first time that P-Rex1 was an essential signaling mediator in CFs activation and subsequent cardiac fibrosis, and 1A-116 could be a potential pharmacological development drug.

Keyphrases

angiotensin ii
angiotensin converting enzyme
vascular smooth muscle cells
left ventricular
high glucose
liver fibrosis
heart failure
emergency department
risk assessment
endothelial cells