Transcriptional profiling of embryos lacking the lipoprotein receptor SR-B1 reveals a regulatory circuit governing a neurodevelopmental or metabolic decision during neural tube closure.

Nicolás SantanderCarlos LizamaLeandro MurgasSebastián ContrerasAlberto J M MartinPaz MolinaAlonso QuirozKatherine RiveraFrancisca Salas-PérezAlejandro GodoyAttilio RigottiDolores Busso

Published in: BMC genomics (2018)

Our analysis shows that normal and defective embryos lacking SR-B1 have divergent expression profiles, explained by a defined set of transcription factors that may explain their divergent phenotype. We propose that distinct expression profiles may be relevant during early development to support embryonic nutrition and neural tube closure.

Keyphrases

transcription factor
gene expression
physical activity
dna binding
single cell
decision making
heat shock
binding protein
congenital heart disease